Dextran Coated Iron Oxide Nanoparticles – Streptavidin, Fluorescent Dye (optional)

Description

Dextran coated iron oxide nanoparticles – streptavidin & fluorescent dye

General Information

Fluorescent, Streptavidin functionalized Dextran coated iron oxide nanoparticles (CLIO-STRP-D) have 1-3 superparamagnetic Fe3O4 iron oxide cores (8-10 nm in diameter) imbedded within the matrix of dextran strands of 40 or 70 kDa in size. Dextran strands are crosslinked to prevent their disassociation, ensuring long-term stability. Streptavidin and fluorescence dye are covalently conjugated to the nanoparticle surface.

Features

• Superparamagnetic
• Fluorescently labeled (AFDye 488, AFDye 555, AFDye 647, or IR750 dye)
• Highly biocompatible, non-toxic
• Long term stable under physiological conditions
• 40 kDa and 70 kDa dextran coats are available
• Easy loading of biomolecules such as Antibodies through Streptavidin-Biotin interaction

Applications

• In vitro and in vivo dual magnetic and fluorescence labels for cells and tissues.
• Magnetic, fluorescence, or dual cell separation.
• Probes for MRI.

Specifications

• Fluorescent Dye:
  • AFDye 488 (AlexaFluor 488 analog, Abs/Em = 490/525, Filter set: FITC)
  • AFDye 555 (AlexaFluor 555 analog, Abs/Em = 555/580, Filter set: TRITC)
  • AFDye 647 (AlexaFluor 647 analog, Abs/Em = 650/665, Filter set: Cy5)
  • IR750 (IRDye 750 analog, Abs/Em = 756/776, Filter set: Cy7)
• Iron Oxide Core Diameter: 8 – 10 nm
• Hydrodynamic Diameter: 70 – 130 nm
• Polydispersity Index (PDI): < 0.3
• Magnetization:  5 – 30 emu/g (room temperature)
• Shelf life: > 1 year (4°C storage)
• Supplied as liquid suspension in sterile PBS

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