Hyacinth Deblocking Reagent – 3% DCA in Toluene

Description

Hyacinth Deblocking Reagent – 3% Dichloroacetic Acid in Toluene for DNA/RNA Synthesis

Hyacinth Deblocking Reagent is a 3% (v/v) solution of dichloroacetic acid (DCA) in toluene, formulated for gentle and precise deblocking in phosphoramidite-based oligonucleotide synthesis. Used during the detritylation step, this reagent efficiently removes the 5’-DMT protecting group without overexposure or degradation of sensitive sequences.

With a lower acid concentration than standard 10% DCA solutions, Hyacinth is particularly suited for protocols where reaction control, milder conditions, or higher synthesis fidelity is essential — including long oligos or modified bases.

Key Features:

• 3% dichloroacetic acid (DCA) in toluene
• Low-strength deblocking for 5’-DMT removal
• High-purity formulation for DNA and RNA synthesis
• Compatible with both manual and automated synthesizers
• Ideal for sensitive or high-precision oligo synthesis

Applications:

• Deblocking step in oligonucleotide synthesis
• Detritylation under mild conditions
• Long or modified oligo workflows
• DNA/RNA synthesis requiring slower DMT removal

Distribution:

• Available across Denmark, Sweden, Norway, and Iceland
• Fast delivery and expert support from YouDoBio