PLGA Nanoparticles

Description

PLGA Nanoparticles Carboxyl Functionalized

The single-layer Poly(lactic-co-glycolic acid) (PLGA) nanoparticles from Luna Nanotech are expertly engineered nanostructures. They feature a hydrophobic core encapsulated within a hydrophilic shell, providing an ideal architecture for various applications.

Key Features and Properties:

• Surface Functionality: The PLGA surface prominently contains COOH (carboxyl) groups. These groups are highly reactive and can be effectively used for EDC/NHS based bioconjugation, allowing for covalent attachment of biomolecules.
• Optional Surface Modifications:
  • Methoxy PEG: This modification can significantly improve the in vivo blood half-life of the nanoparticles, making them more suitable for systemic delivery applications.
  • PEG-Azide: This modification enables the covalent attachment of biomolecules via click chemistry, offering precise control over functionalization.
• Biocompatible & Biodegradable: These nanoparticles are manufactured using FDA-approved biocompatible and biodegradable PLGA polymer, ensuring their safety and utility in biological systems.
• High Monodispersity: They exhibit a high degree of monodispersity, meaning the nanoparticles are uniform in size, which is critical for consistent and reproducible experimental results.
• Format: Supplied as a convenient lyophilized powder.

Applications of carboxyl PLGA Nanoparticles: These versatile PLGA nanoparticles can be utilized effectively in both in vitro (laboratory-based) and in vivo (within living organisms) settings. Their primary applications include:

1. Protein Delivery: Efficient encapsulation and controlled release of therapeutic proteins.
2. Small Molecule Delivery: Targeted delivery and sustained release of various small molecule drugs.
3. Controlled Release Systems: Development of advanced systems for the prolonged and regulated release of encapsulated active agents.

Product is supplied as lyophilized powder.