Streptavidin Magnetic Nanoparticles: PLGA Nanoparticles, Streptavidin Coated, with optional Fluorescent and Magnetic Properties
Price range: €690.00 through €1,440.00
Our single-layer poly (lactic-co-glycolic acid) (PLGA) nanoparticles form nanostructures with a hydrophobic core encapsulated inside a hydrophilic shell. Streptavidin protein is covalently conjugated to the surface of the PLGA nanoparticles. Dye molecules and magnetic nanoparticles can be encapsulated inside the hydrophobic core.
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Description
Streptavidin Magnetic Nanoparticles, with Optional Fluorescent and Magnetic Properties
These streptavidin magnetic nanoparticles come with the option to customize both magnetic properties and fluorescent labels. Our single-layer poly (lactic-co-glycolic acid) (PLGA) nanoparticles form nanostructures with a hydrophobic core encapsulated within a hydrophilic shell. The Streptavidin protein is covalently conjugated to the surface of the PLGA nanoparticles, providing a robust platform for bioconjugation. Dye molecules and magnetic nanoparticles are encapsulated within the hydrophobic core, providing both fluorescent and magnetic functionality.
The PLGA polymer is made with an FDA-approved biocompatible and biodegradable material. This versatile system allows for the easy loading of antibodies, proteins, and small molecules through the strong Streptavidin-Biotin interaction. It also offers a high degree of monodispersity and the option to be pulled down by an applied magnetic force.
LGA surface contains COOH groups that can be used for EDC/NHS based bioconjugation. Optional surface modifications include methoxy PEG (improves in vivo blood half-life) and PEG-Azide (can be used to covalently attach biomolecules by click chemistry).
Features
- Made with FDA approved biocompatible and biodegradable PLGA polymer.
- Easy loading of antibodies, proteins, and small molecules through Streptavidin – Biotin interaction.
- High degree of monodispersity.
- (Optional) Can be pulled down by application of magnetic force.
- (Optional) Labeled with a fluorescent dye.
This technology has three established applications:
- In vitro and in vivo delivery of proteins and small molecules: The nanoparticles serve as effective carriers, protecting therapeutic agents and facilitating targeted delivery.
- Magnetic cell pulldown and flow cytometry analysis: The magnetic property allows for the isolation of specific cells, while the fluorescent label enables detailed analysis.
- Dual fluorescence and MRI imaging: The combined fluorescent and magnetic properties allow for a powerful dual-mode imaging approach for both in vitro and in vivo studies.
Fluorescent Dye Label Options: DiR, DiD, DiI, DiO, None
Magnetic Label Options: Magnetic, None
Volume Options: 1 mL, 2 mL (@ 5mg/mL)
Product is supplied as suspension in 1X PBS, pH 7
Additional information
| Fluorescent Dye Label | None, DiO (Green), Dil (Orange/Red), DiD (Far Red), DiR (Near IR) |
|---|---|
| Magnetic Functionality | None, Magnetic |
| Scale | 1 mL (@ 5 mg/mL), 2 mL (@ 5 mg/mL) |
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